解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
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公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The Asia-Oceanian region is the most populous region in the world. Although there has been substantial economic development and improvement in health services in recent years, epilepsy remains generally an underrecognized and understudied condition. To help promote research in the region, the Commission on Asian and O...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12957
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To examine antioxidative system in hippocampi of patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (mTLE-HS). METHODS:Activity and levels of antioxidative enzymes-catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), manganese superoxide dismutase (MnSOD), ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12981
更新日期:2015-05-01 00:00:00
abstract::The purpose of this study was to determine whether seizure frequency and cycle days with seizure occurrence vary across the menstrual cycle. The subjects were the first 100 women with intractable focal onset seizures, 13-45 years old, who completed the baseline phase of the National Institutes of Health (NIH) Progeste...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12969
更新日期:2015-05-01 00:00:00
abstract::Genetic factors play a major role in the etiology of juvenile myoclonic epilepsy (JME), a common form of idiopathic generalized epilepsy, but so far, genes related to JME remain largely unknown. JME shares electroclinical features with Unverricht-Lundborg disease (progressive myoclonic epilepsy type 1; EPM1), a form o...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12944
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:To investigate whether the link between epilepsy and deprivation is due to factors associated with deprivation (social causation) or factors associated with a diagnosis of epilepsy (social drift). METHODS:We reviewed electronic primary health care records from 2004 to 2010, identifying prevalent and incident...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12942
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:To explore the structure-function relation of the temporal lobe in newly diagnosed West syndrome of unknown cause (uWS). METHODS:Quantitative magnetic resonance imaging (three-dimensional [3D] structural MRI and diffusion tensor imaging [DTI]) was analyzed using voxel-based morphometry (VBM) and tract-based ...
journal_title:Epilepsia
pub_type: 杂志文章,多中心研究
doi:10.1111/epi.12907
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:To develop a better understanding of mechanisms of seizures and long-term epileptogenesis using neurocysticercosis. METHODS:A workshop was held bringing together experts in epilepsy and epileptogenesis and neurocysticercosis. RESULTS:Human neurocysticercosis and parallel animal models offer a unique opportu...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/epi.12849
更新日期:2015-02-01 00:00:00
abstract::Postictal refractoriness checked by paired stimulations of the limbic structures was demonstrated to fail in rats<2 weeks old. Cortical epileptic afterdischarges were used in our study to examine if this phenomenon is restricted to old cortical structures or if it is a general one. Rats 12, 15, 18, 25, and 90 days old...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12870
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:Patients with temporal lobe epilepsy (TLE) experience significant deficits in category-related object recognition and naming following standard surgical approaches. These deficits may result from a decoupling of core processing modules (e.g., language, visual processing, and semantic memory), due to "collate...
journal_title:Epilepsia
pub_type: 临床试验,杂志文章
doi:10.1111/epi.12860
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Hemispherectomy is an established surgical treatment for carefully selected pediatric patients with intractable epilepsy. Published perioperative data report low mortality rates and seizure reduction rates of 50-89%. This study investigates trends in the demographics, hospital utilization, and in-hospital com...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12869
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To assess incidence, prevalence, risk factors, and prognosis of peripartum depression and anxiety in a prospective study of women with epilepsy. METHOD:Pregnancies in women with epilepsy (n=706) were compared to pregnancies in all women without epilepsy (n=106,511) including women with specified nonepileptic...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12884
更新日期:2015-01-01 00:00:00
abstract::This study aimed to determine clinical features of adult patients with gelastic seizures recorded on video -electroencephalography (EEG) over a 5-year period. We screened video-EEG telemetry reports for the occurrence of the term "gelastic" seizures, and assessed the semiology, EEG features, and duration of those seiz...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12868
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:The cardiac component of risk for sudden unexpected death in epilepsy (SUDEP) and alterations in cardiac risk by vagus nerve stimulation (VNS) are not well understood. We determined changes in T-wave alternans (TWA), a proven noninvasive marker of risk for sudden cardiac death in patients with cardiovascular ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12855
更新日期:2014-12-01 00:00:00
abstract::We predicted vigabatrin dosages for adjunctive therapy for pediatric patients with refractory complex partial seizures (rCPS) that would produce efficacy comparable to that observed for approved adult dosages. A dose-response model related seizure-count data to vigabatrin dosage to identify dosages for pediatric rCPS ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12825
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:Organophosphates (OPs) are commonly used insecticides for agriculture and domestic purposes, but may also serve as nerve agents. Exposure to OPs result in overstimulation of the cholinergic system and lead to status epilepticus (SE), a life-threatening condition that is often resistant to treatment. SE is ass...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12838
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:Originally derived from a Wistar rat strain, a proportion of which displayed spontaneous absence-type seizures, Genetic Absence Epilepsy Rats from Strasbourg (GAERS) represent the most widely utilized animal model of genetic generalized epilepsy. Here we compare the seizure, behavioral, and brain morphometric...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12840
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:Mutations involving the cyclin-dependent kinase-like 5 (CDKL5) gene cause an early onset epileptic encephalopathy (EE) with severe neurologic impairment and a skewed 12:1 female-to-male ratio. To date, 18 mutations have been described in boys. We analyzed our cohort of boys with early onset EE to assess the d...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12803
更新日期:2014-11-01 00:00:00
abstract::Optogenetics is a novel technology that combines optics and genetics by optical control of microbial opsins, targeted to living cell membranes. The versatility and the electrophysiologic characteristics of the light-sensitive ion-channels channelrhodopsin-2 (ChR2), halorhodopsin (NpHR), and the light-sensitive proton ...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/epi.12804
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to systematically review the literature on the interictal language profile in adult patients with epilepsy. METHODS:An extensive literature search was performed using MEDLINE, Embase, PsycINFO, Cochrane Central Register of Controlled Trials, PASCAL, and PSYNDEXplus databases. Ke...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/epi.12743
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:Depression is a common comorbidity of epilepsy, and its timely identification in persons with epilepsy is essential. The use of screening tools to detect depression is common in epilepsy, but some scales in current use have not been validated using a gold standard in this population. The present study aims to...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12754
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVES:Health-related quality of life (HRQOL) is an important indicator of well-being in patients with epilepsy. When assessing changes in HRQOL over time, some of the changes observed may be due to the patients' change in the internal standards, value, or meaning that they attribute to the HRQOL domain being measu...
journal_title:Epilepsia
pub_type: 杂志文章,随机对照试验
doi:10.1111/epi.12697
更新日期:2014-09-01 00:00:00
abstract::This chapter covers the syndromes of benign epilepsy with centrotemporal spikes (BECTS), nonlesional focal epilepsy in otherwise normal children (NLFN), and the genetic generalized epilepsies. BECTS is an epilepsy syndrome that always enters terminal remission before the general age of a planned transition of adolesce...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/epi.12706
更新日期:2014-08-01 00:00:00
abstract::We present a 4-year-old girl with profound global developmental delay and refractory epilepsy characterized by multiple seizure types (partial complex with secondary generalization, tonic, myoclonic, and atypical absence). Her seizure semiology did not fit within a specific epileptic syndrome. Despite a broad metaboli...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12663
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:We examine improvement and worsening in quality of life (QOL) in terms of proportions achieving minimum clinically important change (MCID), and factors related to MCID, in patients with temporal lobe epilepsy randomized to medical or surgical treatment. METHODS:Eighty patients with temporal lobe epilepsy ran...
journal_title:Epilepsia
pub_type: 杂志文章,随机对照试验
doi:10.1111/epi.12625
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:The annual prevalence of antiepileptic drug (AED) prescribing reported in the literature differs considerably among European countries due to use of different type of data sources, time periods, population distribution, and methodologic differences. This study aimed to measure prevalence of AED prescribing ac...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12557
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:The co-occurrence of absence and mesial temporal lobe epilepsy is rare in both humans and animal models. Consistent with this, rat models of absence epilepsy, including genetic absence epilepsy rats from Strasbourg (GAERS), are resistant to experimental temporal lobe epileptogenesis, in particular by amygdala...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12592
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:In CSWS (continuous spike waves during sleep) activation of spike waves during slow wave sleep has been causally linked to neuropsychological deficits, but the pathophysiologic mechanisms are still unknown. In healthy subjects, the overnight decrease of the slope of slow waves in NREM (non-rapid eye movement)...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12576
更新日期:2014-04-01 00:00:00
abstract::Epilepsy was defined conceptually in 2005 as a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. This definition is usually practically applied as having two unprovoked seizures >24 h apart. The International League Against Epilepsy (ILAE) accepted recommendations of a t...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/epi.12550
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:Few studies have examined the long-term sustainability of complete seizure freedom on the ketogenic diet (KD). The purpose of this study was to describe the risk of seizure recurrence in children who achieved at least 1 month of seizure freedom on the KD, and to assess clinical features associated with sustai...
journal_title:Epilepsia
pub_type: 杂志文章,随机对照试验
doi:10.1111/epi.12583
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:To identify the brain networks that are involved in the different electroencephalography (EEG) abnormalities in patients with ring chromosome 20 [r(20)] syndrome. We hypothesize the existence of both distinctive and common brain circuits for the paroxysmal high voltage sharp waves (hSWs), the seizures, and th...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12539
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:Seizures are common in individuals with duplications of chromosome 15q11.2-q13 (Dup15q). The goal of this study was to examine the phenotypes and treatments of seizures in Dup15q in a large population. METHODS:A detailed electronic survey was conducted through the Dup15q Alliance containing comprehensive que...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12530
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:Seizures are currently defined by their electrographic features. However, neuronal networks are intrinsically dependent on neurotransmitters of which little is known regarding their periictal dynamics. Evidence supports adenosine as having a prominent role in seizure termination, as its administration can ter...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12511
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:Previous validation studies assessing the use of administrative data to identify patients with epilepsy have used targeted sampling or have used a reference standard of patients in the neurologist, hospital, or emergency room setting. Therefore, the validity of using administrative data to identify patients w...
journal_title:Epilepsia
pub_type: 杂志文章,随机对照试验
doi:10.1111/epi.12506
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVES:To validate and translate the English version of the Neurologic Depression Disorders Inventory in Epilepsy (NDDI-E) into Spanish as a screening instrument for major depressive episodes (MDE) for patients with epilepsy from Argentina and Uruguay. METHODS:One hundred fifty-five consecutive outpatients with ep...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12503
更新日期:2014-02-01 00:00:00
abstract::Advanced variant detection in genes underlying risk of sudden unexpected death in epilepsy (SUDEP) can uncover extensive epistatic complexity and improve diagnostic accuracy of epilepsy-related mortality. However, the sensitivity and clinical utility of diagnostic panels based solely on established cardiac arrhythmia ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12489
更新日期:2014-02-01 00:00:00
abstract::The ultimate treatment goal in epilepsy therapy is always freedom from seizures with as few treatment adverse effects as possible. If seizures persist with the first monotherapy, alternative monotherapy with another antiepileptic drug (AED) should be considered. Continuing seizures should lead to a reevaluation of dif...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12494
更新日期:2014-01-01 00:00:00
abstract::This study sought to determine the frequency and clinical significance of nonhabitual seizures in 101 consecutive patients undergoing presurgical intracranial electroencephalography intracranial (icEEG) recording. We compared clinical data, recording details, and postsurgical outcome in patients with nonhabitual seizu...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12462
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:Potentially pathogenic autoantibodies are found increasingly in adults with seizure disorders, including focal seizures and those of unknown cause. In this study, we investigated a cohort of children with new-onset seizures to see whether there were autoantibodies and the relationship to any specific seizure or...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12405
更新日期:2013-12-01 00:00:00
abstract::Use of antiepileptic drugs (AEDs) in pregnant women with epilepsy (WWE) is associated with an increased risk of major congenital malformations (MCM). Previous studies have suggested that WWE who had a malformation in their index pregnancy were at an increased risk of recurrence in future pregnancies. We aimed to asses...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12411
更新日期:2013-12-01 00:00:00
abstract::Epilepsy is a disease of recurrent seizures that can be associated with a wide variety of acquired and developmental brain lesions. Current medications for patients with epilepsy can suppress seizures; they do not cure or modify the underlying disease process. On the other hand, surgical removal of focal brain regions...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/epi.12441
更新日期:2013-12-01 00:00:00